Prostate Cancer High Risk
Reviewed by Oncology Team, VICI Healthcare | Last updated: 2026-04
What High Risk Means
Stage T3a OR Gleason 8–10 OR PSA >20 ng/mL
Treatment Approach for High Risk
Definitive therapy + ADT. EBRT – 24–36 months ADT preferred if fit. Consider adding docetaxel in high-grade disease. Surgery if candidate and node-negative on imaging.
Survival Rates and Prognosis
The 5-year survival rate for prostate cancer at High Risk is approximately 88%–93% (10-yr: 75%–85%). Survival rates are statistical averages drawn from large patient populations and may not reflect your individual outcome. Factors that influence your specific prognosis include your age, overall health, tumour biology, and how well the cancer responds to treatment.
Important: These numbers are drawn from historical data. Newer treatments available today may improve outcomes beyond what published statistics show. Discuss your individual prognosis with your oncologist.
How Other Stages Compare
| Stage | 5-Year Survival | Treatment |
|---|---|---|
| Very Low Risk | 99%+ (10-yr: 98%+) | Active surveillance preferred. Annual PSA, DRE, repeat biopsy in 1–2… |
| Low Risk | 98%+ (10-yr: 95%) | Active surveillance or definitive therapy (RARP or radiation). Discuss 10-year… |
| Intermediate Risk | 95% (10-yr: 88%–92%) | Definitive therapy: RARP with or without pelvic lymph node dissection, or EBRT… |
| Very High Risk | 70%–85% (10-yr: 55%–75%) | Aggressive systemic therapy. EBRT – 36+ months ADT with or without… |
| Metastatic Hormone-Sensitive (mHSPC) | 40%–60% (10-yr: 10%–25%) | Upfront ADT + docetaxel (STAMPEDE/CHAARTED trials showed docetaxel improves… |
| Metastatic Castration-Resistant (mCRPC) | 15%–30% (10-yr: <10%) | Sequence of hormone therapies (abiraterone, enzalutamide, apalutamide) or… |
Prostate Cancer Treatment in Top Cities
Prostate Cancer in Gurgaon
Prostate Cancer in Noida
Prostate Cancer in Mumbai
Prostate Cancer in Bangalore
Prostate Cancer in Hyderabad
Prostate Cancer in Chennai
Prostate Cancer in Kolkata
Diagnosed with High Risk Prostate Cancer?
Our specialists can review your reports and create a personalised treatment plan.