Prostate Cancer Intermediate Risk
Reviewed by Oncology Team, VICI Healthcare | Last updated: 2026-04
What Intermediate Risk Means
Stage T2b–T2c OR Gleason 7 OR PSA 10–20 ng/mL
Treatment Approach for Intermediate Risk
Definitive therapy: RARP with or without pelvic lymph node dissection, or EBRT – 6 months ADT. Risk stratification within this group important; higher-grade intermediate may warrant 2–3 years ADT.
Survival Rates and Prognosis
The 5-year survival rate for prostate cancer at Intermediate Risk is approximately 95% (10-yr: 88%–92%). Survival rates are statistical averages drawn from large patient populations and may not reflect your individual outcome. Factors that influence your specific prognosis include your age, overall health, tumour biology, and how well the cancer responds to treatment.
Important: These numbers are drawn from historical data. Newer treatments available today may improve outcomes beyond what published statistics show. Discuss your individual prognosis with your oncologist.
How Other Stages Compare
| Stage | 5-Year Survival | Treatment |
|---|---|---|
| Very Low Risk | 99%+ (10-yr: 98%+) | Active surveillance preferred. Annual PSA, DRE, repeat biopsy in 1–2… |
| Low Risk | 98%+ (10-yr: 95%) | Active surveillance or definitive therapy (RARP or radiation). Discuss 10-year… |
| High Risk | 88%–93% (10-yr: 75%–85%) | Definitive therapy + ADT. EBRT – 24–36 months ADT preferred if fit…. |
| Very High Risk | 70%–85% (10-yr: 55%–75%) | Aggressive systemic therapy. EBRT – 36+ months ADT with or without… |
| Metastatic Hormone-Sensitive (mHSPC) | 40%–60% (10-yr: 10%–25%) | Upfront ADT + docetaxel (STAMPEDE/CHAARTED trials showed docetaxel improves… |
| Metastatic Castration-Resistant (mCRPC) | 15%–30% (10-yr: <10%) | Sequence of hormone therapies (abiraterone, enzalutamide, apalutamide) or… |
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