Skin Cancer Melanoma Stage II (T3–4, N0, M0)
Reviewed by Oncology Team, VICI Healthcare | Last updated: 2026-04
What Melanoma Stage II (T3–4, N0, M0) Means
Breslow thickness: >4.0 mm ± ulceration. May be T1–2 with ulceration. No nodal involvement, no distant metastases. High recurrence risk.
Treatment Approach for Melanoma Stage II (T3–4, N0, M0)
Wide local excision (10–20 mm margins). SLNB strongly recommended. Adjuvant systemic therapy: checkpoint inhibitor (pembrolizumab, nivolumab) or BRAF-targeted therapy if BRAF+ (dabrafenib + trametinib) substantially improves recurrence-free survival. Duration: 1 year for most high-risk stage II. Follow-up: clinical exams every 3 months for 2 years, then 6-monthly; imaging if symptoms or increasing LDH.
Survival Rates and Prognosis
The 5-year survival rate for skin cancer at Melanoma Stage II (T3–4, N0, M0) is approximately 5-year survival: 60–75% (stage IIA–IIB); 50–60% (stage IIC). Survival rates are statistical averages drawn from large patient populations and may not reflect your individual outcome. Factors that influence your specific prognosis include your age, overall health, tumour biology, and how well the cancer responds to treatment.
Important: These numbers are drawn from historical data. Newer treatments available today may improve outcomes beyond what published statistics show. Discuss your individual prognosis with your oncologist.
How Other Stages Compare
| Stage | 5-Year Survival | Treatment |
|---|---|---|
| Non-Melanoma: Low-Risk BCC/SCC | 5-year recurrence-free survival: >95% | Mohs micrographic surgery (preferred), wide local excision, curettage and… |
| Non-Melanoma: High-Risk BCC/SCC | 5-year recurrence-free survival: 50–80%; metastatic risk 5–20% for aggressive SCC variants | Mohs micrographic surgery or wide local excision with adequate margins (5–10… |
| Melanoma Stage I (T1–2, N0, M0) | 5-year survival: 85–95% (stage IA); 70–80% (stage IB) | Wide local excision (10–20 mm margins depending on thickness and anatomic… |
| Melanoma Stage III (T1–4, N1–3, M0) | 5-year survival: 50–70% (stage IIIA); 40–50% (stage IIIB); 25–40% (stage IIIC) | Complete lymph node dissection (CLND) historically standard; trend toward… |
| Melanoma Stage IV (Any T, Any N, M1) | 5-year survival: 20–40% (with modern immunotherapy/targeted therapy); 5–15% (historical, pre-checkpoint inhibitor era) | Systemic therapy: (1) Checkpoint inhibitor monotherapy (pembrolizumab,… |
| Merkel Cell Carcinoma (Stage I–IV) | 5-year survival: 70–80% (stage I); 50% (stage II–III); 25% (stage IV) | Stage I–II: wide local excision (1–2 cm margins) + SLNB + adjuvant radiation…. |
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Diagnosed with Melanoma Stage II (T3–4, N0, M0) Skin Cancer?
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